TEAD4, which is a member of the Hippo signaling pathway, is overexpressed in various cancers and it requires coactivators, such as Yes-associated protein (YAP) or transcription coactivator with a PDZ-binding motif (TAZ) to induce the expression of c-myc, Axl, survivin, CTGF, cyr61, and VEGF-A [15,16,17]. The gene discussed is YAP1; the disease is cancer.