TOP2A and non-small cell lung carcinoma: Using Gene Expression Profiling Interactive Analysis (GEPIA), a newly developed interactive web server for analyzing RNA-Seq expression data, we confirmed on NSCLC datasets retrieved from TCGA and GTEx projects that TOP2A (P < 0.05), SLC2A1 (P < 0.05), TPX2 (P < 0.05), and ASPM (P < 0.05) were upregulated in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) specimens, compared to adjacent normal lung samples (Figure 4A–4D).