SLC40A1 and Mental deterioration: In above, the compounds of effective components of Epimedium, Astragaoside and Puerarin improved memory and cognitive decline, decreased the Aβ-42 in AD model mice, downregulated iron uptake protein DMT1-with/without IRE, TF, TfR1 expression, upregulated iron release protein FPN1, CP, HEPH expression and downregulated the iron storage protein Ferrtin and iron regulated hormone hepcidin.