Immunohistochemical staining revealed that the Integral optical density (IOD) of DMT1-with/without IRE, TF, ferritin, hepcidin expression in AD transgenic model group were higher than in C57 wild-type group (Figure 5, P < 0.05), while the IOD of FPN1, HEPH, CP were lower (P < 0.05) in the AD transgenic model group. The gene discussed is SLC11A2; the disease is Alzheimer disease.