Taken together, the compounds of effective components of Epimedium, Astragaoside, Puerarin improved memory and cognition impairment, decreased the accumulation of Aβ-42 in AD model mice, downregulated the expression of iron uptake protein DMT1-with/without IRE, TF, TfR1expression. The gene discussed is SLC11A2; the disease is Alzheimer disease.