In above, the compounds of effective components of Epimedium, Astragaoside and Puerarin improved memory and cognitive decline, decreased the Aβ-42 in AD model mice, downregulated iron uptake protein DMT1-with/without IRE, TF, TfR1 expression, upregulated iron release protein FPN1, CP, HEPH expression and downregulated the iron storage protein Ferrtin and iron regulated hormone hepcidin. Here, HAMP is linked to Alzheimer disease.