However, this result conflicted with those of a previous study reporting that Nrg4 stimulates insulin secretion and controls de novo liver lipid synthesis under metabolic stress in mice [9], and this study also revealed increased Nrg4 expression could improve insulin resistance and glucose intolerance, thus suggesting the prospect of treating obesity-related comorbidities such as diabetes. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.