In contrast, the expanded populations of CD4+ T cells shortly after peak viral load following experimental infection showed that the majority of responses shared by multiple individuals were directed against the internal proteins NS1, NS2, and M (recognized by CD8+ T cells) and the surface glycoproteins F and G (mainly recognized by CD4+ T cells), all of which are encoded early in the genome and expressed in relative abundance. The gene discussed is LZTR1; the disease is infection.