Why the evolution of a completely anthropoid primate-specific GAAT sequence motif in the G6PC promoter that enables inhibition of G6PD to become irreversible in the presence of DHEAAnd why UOX deletion, leading to accumulation of circulating uric acid, and the disease of gout? It is extremely unlikely that so many longstanding, unresolved questions in primate evolution all intersect at kill switch function, and obtain compelling explanation by such intersection, if that is not where they derive their evolutionary significance. This evidence concerns the gene UOX and gout.