MAPT and Cognitive impairment: In contrast, tau PET studies found that tau deposition occurs mainly in medial and inferior temporal areas, with partial involvement of the parietal and occipital lobes in patients with mild cognitive impairment and Alzheimer’s disease dementia (Villemagne et al., 2015; Cho et al., 2016a; Johnson et al., 2016; Schöll et al., 2016; Mattsson et al., 2017).