MAPT and Mental deterioration: Moreover, based on previously reported associations between tau pathology, white matter degeneration, gray matter atrophy and cognitive decline (Villemagne et al., 2015; Bejanin et al., 2017; Aschenbrenner et al., 2018; Jacobs et al., 2018; Sintini et al., 2019; Strain et al., 2018), we expected to find a stronger correlation between the tau networks, white matter integrity, gray matter volume and cognitive impairment.