MAPT and Cognitive impairment: In addition, although a few studies have looked into the spatial patterns of amyloid-β and tau, none of them studied both of these patterns across the Alzheimer’s disease continuum (Jack et al., 2018) in individuals that are cognitively normal as well as patients with mild cognitive impairment and dementia (Myers et al., 2014; Brier et al., 2016; Jones et al., 2017; Sepulcre et al., 2017a; Hoenig et al., 2018).