Since the accumulation of tau in temporal regions and alterations of the default-mode network are both important imaging markers that can be observed since early stages of Alzheimer’s disease (Sperling et al., 2009; Sepulcre et al., 2017a; Sepulcre et al., 2017b), it is interesting to see that they both came out as connected components in our analyses, which could potentially reflect the interaction between the two proteinopathies in early disease stages. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.