In murine 4T1 and LLC cells (breast and lung tumor, respectively), as well as in human CAPAN-1 pancreatic adenocarcinoma, the VEGFA and VEGFC IRESs are activated after 24 hr of hypoxia whereas the EMCV IRES is not activated (Morfoisse et al., 2014). The gene discussed is VEGFA; the disease is pancreatic adenocarcinoma.