Moreover, osimertinib has recently been further approved as first-line therapy for EGFR-mutant NSCLC expressing L858R or exon 19 deletion variant, based on the superior outcome when compared with the first-generation EGFR-TKIs (gefitinib or erlotinib) in the randomized phase III FLAURA study [42]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.