These mutations drive the development of AD pathological hallmarks such as the production of toxic Aβ-species, extraneuronal deposition of amyloid plaques as well as hyperphosphorylation of Tau protein and intraneuronal accumulation of neurofibrillary tangles (NFTs), recapitulating critical traits of AD in humans [3, 62, 64, 65]. Here, MAPT is linked to Alzheimer disease.