At this age, earlier studies demonstrated that these mice exhibit robust AD-like tauopathy including Tau hyperphosphorylation and pathological Tau phosphorylation, formation of intracellular neurofibrillary tangles-like Gallyas silver-positive inclusions, Tau filaments, ghost tangles, and gliosis, in several brain regions including CA1 [63]. The gene discussed is MAPT; the disease is Alzheimer disease.