Compared with the sham group, the expressions of NLRP3, cleaved caspase-1 and cleaved IL-1β were significantly increased by CCH, but this increase was significantly attenuated by URB treatment, suggesting that URB could suppress NLRP3-mediated CASP1 activation and mature IL-1β secretion. This evidence concerns the gene IL1B and columnar cell hyperplasia of the breast.