In order to eliminate CCH-induced NLRP3 inflammasome activation, other autophagy adaptor proteins, such as NBR1, optineurin, CALCOCO2 and TAX1BP1, might be employed to deliver NLRP3 inflammasome to the lysosome for degradation in p62-independent mitophagy. The gene discussed is CALCOCO2; the disease is columnar cell hyperplasia of the breast.