TGFB1 and cancer: Interestingly, Whiteside [110] suggested that iTreg cells should be depleted and nTreg cells are promoted in cancer patients, since iTreg cells produce immunosuppressive cytokines, notably TGF-β as well as prostaglandin E2 resistant to oncological therapy, while FOXP3+ nTreg cells are responsible for peripheral tolerance to avoid autoimmune disease [111].