Likewise, FOXP3 downregulation attenuated the expression of LIM Domain Only 2 (LMO2) but increased the expression of an oncogenic transcription factor T-cell acute lymphocytic leukemia protein 1 (TAL1) at mRNA level in T-cell acute lymphoblastic leukemia (T-ALL) cells [181]. Here, TAL1 is linked to acute lymphoblastic leukemia.