Also, FOXP3 is associated with IL-17 [20], RUNX1 [21], STAT3 [22], NF-κB [23], FOXO3 [24] and other cofactors such as EOS (Ikzf4) [25], interferon regulatory factor 4 (IRF4) [26], special AT-rich sequence-binding protein-1 (SATB1) [25, 27] and GATA1, while FOXP4 is closely associated with miR 4316 in breast cancer cells [28], miR 491–5p in osteosarcoma [29] and miR 338-3p in hepatocellular carcinoma [30]. This evidence concerns the gene IRF4 and osteosarcoma.