Thus, Treg cells suppress tumor-specific CD8+ T cell cytotoxicity through TGF-β signaling [101] and some molecules including nuclear factor of activated T cells (NFAT) [15] and Runt-related transcription factor 1 (RUNX1) [92] are found to bind to the promoter regions of FOXP3-regulated genes for activation of Treg cells. This evidence concerns the gene TGFB1 and neoplasm.