FOXP3 promotes the immune evasion as Treg cell marker suppressing immune response against cancer, while FOXP3 at the Xp11.23 revealed good prognosis in breast cancers as a tumor suppressor [85–88] by regulating HER-2/ErbB2 [88] or SKP2 [89, 90] oncogene. This evidence concerns the gene ERBB2 and breast cancer.