Cheng et al. found that exosomes produced by HCC cells could inhibit the activation of immune cells to lead to immune evasion by stimulating macrophages to increase the secretion of IL-6, IL-1β, IL-10, and TNF-α, activating STAT3 pathway, and increasing PD-L1 protein expression. The gene discussed is IL10; the disease is hepatocellular carcinoma.