Studies have shown that when exosomal CAV1, CAV2, and Met protein produced by high motility HCC cell lines are captured by surrounding normal liver cells, the MAPK/PI3K/Akt pathway in target cells is activated, resulting in immortalization and migration, and when captured by HCC cells, the invasiveness of HCC cells increases, indicating that CAV and Met play important roles in HCC metastasis and progression [165, 166]. The gene discussed is MET; the disease is hepatocellular carcinoma.