The significantly increased expression of miR-1247-3p in HCC exosomes can lead to the downregulation of β-1,4-galactosyltransferases III (B4GALT3), activate the integrin β1/NF-κB pathway, and induce the transformation of fibroblasts to CAFs. The gene discussed is NFKB1; the disease is hepatocellular carcinoma.