AFP and hepatocellular carcinoma: Xu et al. reported that the expression levels of ENSG00000258332.1 and LINC000635 in serum exosomes of HCC patients were significantly higher than those of healthy people and LC and CHB patients, and exosomal ENSG00000258332.1 and LINC000635 were positively correlated with HCC lymph node metastasis and TNM stage, but negatively correlated with OS, and further studies showed that combined detection of these two with AFP could significantly improve the detection sensitivity and accuracy of HCC [199].