To verify whether the 3′ UTR of UBE2C, FGF7, FGFR2, FGFR1, IGF2BP1, MET, and CXCR4 mRNAs were targets of miR-381-3p in the NSCLC cells, a pLG3 luciferase reporter gene assay was used. The gene discussed is CXCR4; the disease is non-small cell lung carcinoma.