Further, the activity of ALDH2 was about fivefold lower in the blood of AD patients than age-matched healthy controls (Fig. 4i), and magnetic resonance imaging (MRI) revealed marked atrophy in the left prefrontal lobe and significant ventriculomegaly (marked white triangle) compared to healthy controls (Fig. 4j, k). This evidence concerns the gene ALDH2 and Ventriculomegaly.