These could be CD34− blast cells or leukemia stem cells, which were associated with worsened prognosis and sensitivity to therapy.24 Other megakaryocyte-like large cells were also captured (Supplementary Fig 6b), and their presence was associated with acute megakaryoblastic leukemia.25 The enrichment of CD34− blast cells and megakaryocyte-like cells using the BCB highlight the capability of this technique to identify other leukemia subtypes potentially, and can be subsequently utilized for correlation to patient overall survival. This evidence concerns the gene CD34 and leukemia.