F3666 is a very-low-carbohydrate, low-protein, high-fat ketogenic diet developed to induce efficient production of ketone bodies in rodents.19 In ob/ob mutant mice fed a diet of regular chow, hyperglycemia typically develops at ~10 weeks of age.20 Our initial goal was to reverse this phenotype via feeding mice the LCKD and analyze the diet’s effects on tissues at the molecular level. Here, LEP is linked to Hyperglycemia.