In addition to regulating the expression of many genes that promote tumorigenesis and cancer progression, FOXM1 can also influence these processes through its interactions with other key cellular proteins such as SMAD3 and β-catenin.3 Possible effects of our NB compounds on altering the activity of FOXM1 through these protein interactions remain to be studied in future investigations. The gene discussed is FOXM1; the disease is cancer.