Additionally, macrophages or PBMC from AD patients treated with TLR2 ligands produce significantly less TH1/TH17 cytokines such as interleukin 6 (IL6), IL1β, IFNγ, IL12, and IL17F and IL22, but more TH2 cytokine IL5 [93, 95]. This evidence concerns the gene IL6 and Alzheimer disease.