Type 1 IFNs, including IFNβ from KCs and IFNα from pDCs, serve as early cytokines released upon injury to promote cDC activation and maturation with consequent Th17 T cell development and the beginning of the autoimmune self-amplification loop that drives pathogenic hyperproliferation of KCs and manifestations of psoriasis. Here, IFNB1 is linked to psoriasis.