Upon DAMP or PAMP stimulation, keratinocytes are capable of producing an array of proinflammatory cytokines, such as IFNβ, IL1β, IL36, TNF, IL6, IL8, IL25, and CXCL10, to initiate the inflammatory T cell phenotype in psoriasis [22, 58–60]. Here, IFNB1 is linked to psoriasis.