TLR-2 and TLR-4 expression, cytokine production, and the intracellular growth of M. tuberculosis are not associated with an intrinsic factor in monocytes from T2D patients; however, the presence of high glucose concentrations decreased cytokine production and increased the intracellular growth of M. tuberculosis in monocytes, suggesting that hyperglycemia at high levels may play a key role in altering the immune responses to M. tuberculosis in diabetic patients. Here, TLR4 is linked to Hyperglycemia.