Univariable analysis showed statistical significance in patients of older age (≥ 65 years, p = 0.042), diabetes mellitus (p = 0.001), a non-odontogenic cause of infection (p = 0.004), CRP > 10 mg/dL (p = 0.038), and multiple-space infection (p = 0.049) (Table 4). This evidence concerns the gene CRP and diabetes mellitus.