Moreover, eosinopenia as a controversially discussed marker for sepsis severity [16], [17] and monocytes as potent modulators of inflammation during the SIRS phase and initiators of the subsequent immunosuppressive phase [18] were increased together with neutrophils after E. coli challenge in filariae-infected mice, independent on TGFβ removal. The gene discussed is TGFB1; the disease is Sepsis.