In this study, we first demonstrated that PCDH17 and BECN1 (Beclin 1, which is autophagy-related) were more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues and showed a significant positive relationship between high expression of these genes and superior prognosis. The gene discussed is PCDH17; the disease is colorectal carcinoma.