For example, NADPH oxidase 4 (NOX4) was found to be a predictive factor for relapse in stage II LCC, whereas integrin alpha 3 beta 1 (ITGA3) plays a role in predicting relapse in stage II RCC.27 Gene subtypes might also be associated with drug sensitivity, depending on the location of the tumor. This evidence concerns the gene NOX4 and leukoencephalopathy with calcifications and cysts.