HOXB13 and neoplasm: The myc family consists of proto-oncogenes encode transcription factors that play important roles in regulating cell growth, apoptosis and differentiation.38,39 C-myc is a target gene of the Wnt signaling pathway and activated by the β-catenin/TCF4 complex.40 C Jung et al.16 reported that HOXB13 downregulates TCF4 and C-myc to inhibit β-catenin/TCF-mediated signaling and subsequent tumor growth, which is consistent with our conclusions.