For example, NADPH oxidase 4 (NOX4) was found to be a predictive factor for relapse in stage II LCC, whereas integrin alpha 3 beta 1 (ITGA3) plays a role in predicting relapse in stage II RCC.27 Gene subtypes might also be associated with drug sensitivity, depending on the location of the tumor. The gene discussed is ITGA3; the disease is leukoencephalopathy with calcifications and cysts.