Previous studies have investigated DEGs between RCC and LCC using gene chips and patient samples or gene expression information from databases.22–24 In the present study, DEGs at the intersection of 5 datasets from the GEO were identified, and HOXB13, which has a unique effect on other genes, was the focus of this study because of its impact on overall survival in RCC. This evidence concerns the gene HOXB13 and leukoencephalopathy with calcifications and cysts.