HOXB13 and renal cell carcinoma: The CIMP is characterized by poor prognosis and associated with BRAF mutation, high MSI, and a right-sided tumor location.29–31 In this study, analysis of clinical information from the GEO database showed that more RCC than LCC patients had a positive CIMP status and that CIMP status was related to the downregulation of HOXB13.