The IL-17 is involved in the early phase of the inflammatory process in KOA and upregulates the production of metalloproteinases and decreases the level of proteoglycan (8, 10), whereas other cytokines such as IL-10 and TGF-ß supress inflammation and reduce the rate of osteoarthritis progression (12-15). The gene discussed is IL17A; the disease is osteoarthritis.