SEPTIN5 and Parkinson disease: In order to investigate the possible role of miR-185 and SEPT5 genes in the pathogenesis of PD, their transcript expression level was assessed in SHSY-5Y cell line (a human cell line) treated by rotenone (in vitro model of PD) and brain tissues (substantia nigra and striatum) of male Wistar rat as the in vivo model of PD (induced by rotenone).