In addition, the protein levels of SSADH and SSAR were reduced in some regions after ischemia [71], indicating that GABA metabolism was disturbed, and due to the downregulated SSADH level, the less supplement of GABA shunt to produce adenosine triphosphate (ATP) in pyruvate dehydrogenase into the tricarboxylic acid cycle aggravated the neuron damages. This evidence concerns the gene ALDH5A1 and ischemia.