BACE1 and Alzheimer disease: In addition to being a free radical scavenger against the ROS produced during inflammation within the brain, it has also been reported to ameliorate memory deficits in the amyloid-β- (Aβ1-42-) induced Alzheimer's disease (AD) mouse model by inhibiting β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) activity [16].