In study on human cell line MOLM-13 (acute myeloid leukemia), Guida et al. [71] reported that 1, 2, and 4 isoforms of NOx (Nox1, Nox2, Nox4, respectively), p22phox, and Rac1 gene subunits were expressed in cell lines of myelodysplastic syndrome/acute myeloid leukemia samples with damaged DNA in the nuclear fractions. This evidence concerns the gene NOX4 and acute myeloid leukemia.