The reduction of neither TMEM64 nor S100A4 discriminated well nonosteoporotic controls from osteopenia (area under the ROC curves, 0.6 and 0.55, respectively, not shown) or osteopenia and osteoporosis combined (area under the ROC curves, 0.646 and 0.627, respectively, not shown). This evidence concerns the gene TMEM64 and osteoporosis.