However, for annexin A1 mRNA, when nonosteoporotic controls were compared with osteopenia, the area under the curve was 0.747 (Figure 4(c), 95% CI 0.563 to 0.931; sensitivity 0.556, specificity 0.861) and when compared with osteopenia and osteoporosis combined, the area under the curve was 0.767 (Figure 4(d), 95% CI 0.598 to 0.937; sensitivity 0.556, specificity 0.87). This evidence concerns the gene ANXA1 and osteoporosis.