In conclusion, this study demonstrates for the first time that the levels of mRNAs of annexin A1 and TMEM64 in peripheral blood mononuclear cells are reduced in association with osteoporosis, at least in this group of patients with loss of annexin A1 mRNA in peripheral blood mononuclear cells being a good marker for osteopenia/osteoporosis. This evidence concerns the gene ANXA1 and osteoporosis.