For TMEM64, there was a gradual reduction in the order: nonosteoporotic control, osteopenia, and osteoporosis groups (Figure 1(b) and Table 2; nonosteoporotic control group vs. osteopenia, 95% CI -0.004 to 0.0729, P = 0.0797; nonosteoporotic control group vs. osteoporosis, 95% CI 0.019 to 0.106, P = 0.0052; osteoporosis vs. osteopenia, 95% CI -0.062 to 0.006, P = 0.1, post hoc Bonferroni correction). The gene discussed is TMEM64; the disease is osteoporosis.