Furthermore, the nine key chemical components identified in this study targeted proteins including NR3C1, ESR1, PTGS2, CAT, TNF, INS, and TP53, affecting the MAPK signaling pathway, proteoglycans in cancer, dopaminergic synapse activity, the thyroid hormone signaling pathway, the cAMP signaling pathway, and neuroactive ligand-receptor interaction. This evidence concerns the gene ESR1 and cancer.