Pathway analysis revealed signaling pathways enriched with germline and somatic mutations, many of which have been implicated in PCa including axon guidance; adipogenesis; MSP-RON, RAR, and GP6 activation; and molecular mechanisms of cancer, NF-KB, prostate cancer, GP6, androgen, and VEGF signaling pathways. This evidence concerns the gene MST1R and Familial prostate cancer.