The genes EPHB1, KIAA1614, SACS, SMAD4, PCDHA1, TNS1, CACNA1C, DEPDC1, PCDHGA9, LRP4, KLHL2, CDC20, ARHGEF39, CGNL1, SKIV2L2, FAM196A, IL6ST, ATP2B4, TGFBR3, TIGD3, NOS1, SRSF2, MYO9A, KIF13A, UBR3, WIF1, LRGUK, ERBB4, and NYNRIN had mutations in aggressive PCa only (Table 1). The gene discussed is LRP4; the disease is posterior cortical atrophy.