Pathway analysis revealed signaling pathways enriched with germline and somatic mutations, many of which have been implicated in PCa including axon guidance; adipogenesis; RAR, GP6, thrombin, WINT, MSP-RON, STAT3, PI3K, and TR/RxR activation; and molecular mechanisms of cancer, NF-KB, prostate cancer, GP6, androgen, and VEGF signaling pathways. This evidence concerns the gene STAT3 and Familial prostate cancer.