The genes EPHB1, KIAA1614, SACS, SMAD4, PCDHA1, TNS1, CACNA1C, DEPDC1, PCDHGA9, LRP4, KLHL2, CDC20, ARHGEF39, CGNL1, SKIV2L2, FAM196A, IL6ST, ATP2B4, TGFBR3, TIGD3, NOS1, SRSF2, MYO9A, KIF13A, UBR3, WIF1, LRGUK, ERBB4, and NYNRIN had mutations in aggressive PCa only (Table 1). Here, IL6ST is linked to posterior cortical atrophy.