TNF-α is regarded as one of the most important proinflammatory cytokines in the pathogenesis of IBD, and the TNF-α signaling pathway is also identified to play a vital role in making pleiotropic proinflammatory influence like increasing angiogenesis, activation, and recruitment of macrophage and effective T cells, the direct injure of Paneth cells and intestinal epithelial cells. This evidence concerns the gene TNF and inflammatory bowel disease.