CRP and ESR, which are routinely used for evaluation of the disease activity in IBD, were also analyzed in these patients, and serum hepcidin was identified to be positively correlated with CRP (r = 0.7141, P < 0.0001 in UC; r = 0.6673, P < 0.0001 in CD) and ESR (r = 0.5399, P = 0.0021 in UC; r = 0.5696, P < 0.0001 in CD) in IBD patients, respectively (Figures 1(d)–1(g)). This evidence concerns the gene CRP and inflammatory bowel disease.