Hoshi and the colleagues have described that AQP1 and AQP4 positive cells locate close to Aβ42- or Aβ40-positive senile plaques in the brains of AD patients and speculated that AQP1-positive reactive astrocytes may modify Aβ deposition in the AD brain, while the Aβ deposition process might alter the astrocytic expression of AQP4 [20]. Here, AQP4 is linked to Alzheimer disease.