NOS1 and brain ischemia: For example, immediately following ischemia of the brain, eNOS activity has been shown to be protective and promotes angiogenesis, maintains vascular endothelial function, and regulates vascular tone, whereas neuronal NOS (nNOS) and inducible NOS (iNOS)‐mediated NO production have been associated with subsequent brain damage.10, 11, 12, 13