However, it is clearly related to T cell activation mediated by inhibiting the PD‐1/PD‐L1 and CTLA‐4 pathway.4 ICI‐induced vitiligo may be related to cross‐reactivity against antigens shared by melanoma cells and normal melanocytes.4 T‐cell antigens shared between tumor tissue and skin have been identified in patients with NSCLC, and these antigens were able to activate CD4+ and CD8+ T cells in vitro. Here, CTLA4 is linked to melanoma.