For patients with ILC or IDC‐ILC, a totally opposite result was found, in which more bone and fewer lung metastasis compared with IDC patients, and were in accordance with published articles.27, 28 Based on published articles, we found CDH1 was one of key markers that could distinguish ILC from IDC.29 The loss of expression is observed in the majority of lobular breast carcinomas, CDH1 integrity is impaired.30 On the contrary, the expression is unaffected in ductal breast carcinomas.31 In some articles, roles of CDH1 on distant metastasis of breast cancer have been illustrated. This evidence concerns the gene CDH1 and breast cancer.