CCL27 and breast carcinoma: For instance, Maroni et al reported that CDH1 were expressed in bone metastasis but not in primary breast carcinoma, which playing a pivotal role in bone metastasis colonization.32 Another article also demonstrated crucial roles of CDH1 on promoting bone metastasis.33 The loss of expression of the cell‐cell adhesion molecule CDH1 in ILC might account in part for the different metastatic patterns observed in these types of tumors.