SREBF1 and metastatic neoplasm: Lung, brain, liver, and multiorgan metastatic tumors have similar gene features.13 Another research found that the genomic mutations were originated from the primary tumor and maintained through metastatic spreading, of which TP53 mutation was a recurrent founding mutation in primary and metastatic tumors.14 We also reported genes like NAMPT, SREBP1, and MTDH could drive metastatic progression in TNBC.15, 16, 17 The alteration of genes cluster could not only influence malignant behaviors, but also transform pathomorphological features.