It is reported that the mechanisms of effectiveness are involved in anti‐progesterone, down‐regulation of CDK2, Bcl‐2, growth inhibition of various cancer cell lines, suppression of invasive and metastatic cancer cells, etc.33 However, there are few studies about the application of mifepristone in adenomyosis patients and its mechanism of therapeutic efficacy. This evidence concerns the gene CDK2 and adenomyosis.