TNFSF14 and plasma cell myeloma: MM accounts for 1% of all malignancies and 10% of all hematologic malignancies.1 The revised International Myeloma Working Group (IMWG) criteria allow, in addition to the classic CRAB features (increased calcium level, renal dysfunction, anemia, and destructive bone lesions), myeloma defining events (60% or greater clonal plasma cells on bone marrow examination, serum involved/uninvolved free light chain ratio ≥100, provided the absolute level of the involved light chain is at least 100 mg/L, and more than one focal lesion on MRI that is at least 5 mm or greater in size).