In vitro activation of Dectin-1 with curdlan (a β-1,3-glucan polymer and a selective agonist of the Dectin-1 signaling pathway) induces transcription of the gene encoding IL-12p35 (a subunit of IL-12 that is usually under tight regulation that requires nucleosome remodeling by nuc-2); this appears to be consistent with a key role for Dectin-1 in conferring protection against systemic candidiasis, which relies heavily on Th1 immunity [70, 71, 72]. The gene discussed is CLEC7A; the disease is candidiasis.