CX3CR1 and Crohn disease: A recent study in both mice and humans demonstrated that CLR-expressing colon-resident chemokine receptor CX3CR1+ mononuclear phagocytes could recognize fungi and control gut antifungal T cell immunity in a Syk-dependent manner (e.g., as evidenced by genetic ablation of CX3CR1+ mononuclear phagocytes in mice, and a missense mutation in CXCR1 in Crohn’s disease patients) [109].