CLEC7A and hematologic disorder: For example, patients with hematological malignancies undergoing hematopoietic stem cell transplantation (HSCT) and with an early stop codon polymorphism in Dectin-1 (Y238X) were associated with susceptibility to invasive aspergillosis through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity, and exhibited a higher risk of extrapulmonary invasive Aspergillus infection compared with those harboring WT Dectin-1 [54].