EPHA2 and colitis: In addition, failure to appropriately sense commensal gut fungi through the loss of molecules such as Dectin-1, the non-CLR ephrin type-A receptor 2 (EphA2, expressed on oral epithelium), and SIGNR3 (the closest murine homolog of the human DC-SIGN) has been linked to aggravated disease outcomes (e.g., colitis) as well as to overgrowth of fungi in the gut in both mice and humans [106, 107, 108] (Figure 3).