Nicotine and nicotinic agonists, like 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK), lead to human small cell lung cancer (SCLC) proliferation, while the Ach functional antagonist isoproterenol induced growth of lung adenocarcinoma cells [128]. The gene discussed is FGFR3; the disease is small cell lung carcinoma.