STAT3 and neoplasm: Furthermore, activation of the Interleukin-6 (IL-6)/ Signal transducer and activator of transcription 3 (STAT3)/Aldehyde Dehydrogenase 1 (ALDH1) pathway by adipose tissue-derived vesicles, cytokines, and circulating factors has been recently implicated in tumor stemness and aggressiveness, particularly in breast cancer [19–21].