Salinomycin was reported to induce apoptosis of NSCLC cells through inhibiting the AKT1-mTOR signaling pathway, accompanied by the activation of autophagy; blockage of autophagy augmented salinomycin-mediated apoptosis, suggesting that the autophagic response plays cytoprotective roles [43]. This evidence concerns the gene MTOR and non-small cell lung carcinoma.