Mutations in NF1 (n = 12, 17%) and TP53 (n = 17, 24%) were more frequent in CSDhigh as compared to CSDlow melanoma (NF1: 35% vs. 8%, p = .007; TP53: 48% vs. 12%, p = .002, Fisher's exact test). The gene discussed is NF1; the disease is melanoma.