POU3F3 and hepatocellular carcinoma: It has been confirmed tumour‐derived exosomes tumour antigens and promote tumour development.25 For example, Linc00974 has been identified as biomarker for HCC diagnosis which was involved in TGF‐beta‐associated pathway.17 Besides, long non‐coding RNA POU3F3 in plasma has also proved as a novel biomarker for diagnosis of oesophageal squamous cell carcinoma.26 Here in this study, exosome from plasma was first isolated and identified.