In summary, the findings presented here lead to a model where EWSR1‐ETS‐dependent expression of Ezrin, which can be demonstrated in the vast majority of EwS patient tumor samples, leads to SRC‐independent autophosphorylation of FAK on tyrosine 397 that impairs apoptosis/anoikis and enhances focal adhesion formation as well as Rho‐dependent cell migration of EwS cells. The gene discussed is EWSR1; the disease is neoplasm.