The leading edge genes hosting circRNAs for negative regulation of ATP processes were SNCA, STAT3 and UFSP2, whilst those associated with synaptic vesicle endocytosis were FCH02, PICALM, PIP5K1C and SNCA. Genes hosting circRNAs were primarily localised in pathways involved in phagocytosis, circadian regulation, cancer pathways and golgi-associated vesicle budding in the blood from aged donors (Table 2). This evidence concerns the gene PICALM and cancer.