RNF43 and endometrial cancer: Remarkably, the single most recurrent mutation of RNF43 is deletion of a G-C base-pair (bp) in a seven G repeat near the 3′ end of its open reading frame (nucleotide 1969–1976), accounting for approximately half of all RNF43 mutations detected in colon, stomach, and endometrial cancer with an overall frequency of 5–8%7,14,15.