In colon, endometrial, and stomach cancers, G659Vfs*41 accounted for 40% (23/81), 53% (42/79), and 48% (25/77), respectively, of all RNF43 mutations, whereas not a single G659Vfs*41 mutation (0/13) was found in pancreatic cancer (p < 0.05 vs any of the other three cancer types, Fisher’s exact test). This evidence concerns the gene RNF43 and cancer.