Podocyte susceptibilities could result from the growth factor milieu triggering podocyte mTORC1 activation, hyperglycemia level and exposure time (Fig. 9), metabolic factors including reactive oxygen species, mutations in podocyte-expressed genes such as the Col4α3 gene recently reported to be associated with MODY51, superimposed hypertension and other factors. The gene discussed is COL4A3; the disease is Hyperglycemia.