To determine whether knockdown of Mbl suppresses degeneration caused by other ALS-linked proteins or was specific to FUS-associated ALS, mbl RNAi Drosophila were crossed with lines expressing wild-type or ALS-linked mutant forms of several proteins (EWSR1, TDP-43, dVCP, and C9orf72) (Supplementary Fig. 8). Here, EWSR1 is linked to amyotrophic lateral sclerosis.