HLA-A*01:01, HLA-A*02:01, HLA-A*03:01, HLA-B*08:01, HLA-B*18:01, HLA-B*27:05, HLA-B*37:01, and HLA-B*57:019–11 are associated with universal protective CD8+ T cell mediated immunity, as they present influenza peptides that were highly conserved over the last century. The gene discussed is CD8A; the disease is influenza.